Examples - Maximum Likelihood Models

Maximum Likelihood Models examples

Variations in models using Theophylline data
Variations in models using Phenobarbital data
Variations in Emax models
Fitting PK and PD data and using a simulation run
Variations in models using Propofol data
Logistic regression modeling in Phoenix
Graphically create a peripheral elimination model
Model using logarithmic concentration values (Lyon dataset)
Creating a two dose point model for intravenous and oral data
Covariate modeling with the PK01 dataset
Using a linked indirect response model
Simple PK population analysis using QRPEM
Three category multinomial model with a covariate
Exploring Event, Count, and LL Statements
An example of individual modeling with Maximum Likelihood Model object
Modeling circadian rhythm, inter-occasion variability, and two epsilons

Completed projects for most of these examples are available for reference in …\Examples\NLME. You can save a copy of the Examples directory (installed with Phoenix) to your Phoenix project directory via the Project Settings in the Phoenix Preferences dialog.

Within this directory there are other projects that illustrate one or more aspects of modeling with the Phoenix NLME engines:

•QRPEM_with_time_varying_covariate.phxproj shows how to structure a QRPEM model with time-varying covariates so that QRPEM can run it.

•Remifen.phxproj uses a more complex well-known model that uses nonlinear covariates (“Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil. I. Model Development.” Minto, Charles F.; Schnider, Thomas W.; Egan, Talmage D.; Youngs, Elizabeth; Lemmens, Harry J.; Gambus, Pedro L.; Billard, Valene; Hoke, John F.; Moore, Katherine H.; Hermann, David J.; Muir, Keith T.; Mandema, Jaap W.; Shafer, Steven L. Anesthesiology, January 1997, 86(1): 10–23. Clinical Investigation). This model is restructured so that it can be solved with QRPEM.

Most Phoenix objects require the same basic steps for their use. However, there may be multiple paths to accomplishing a step (e.g., main menu, right-click menu, drag-and-drop, etc.).