Darwin Reporter

Overview page

Diagnostic plots and tables

Darwin Reporter is a Shiny app, integrated in the Certara.DarwinReporter R package. Darwin Reporter extends the functionality of Pirana’s Model Results tool to manage Darwin Search output, extracting information from pyDarwin search output for diagnostics generation in R.

This section highlights the unique aspects of Darwin Reporter, which include the generating:

Mean fitness by iteration and minimum cumulative fitness by iteration plot

Minimum best fitness by iteration plot with fitness composition breakdown by penalties

Diagnostic tables and plots for key models

Options for customizing these plots and the table are described in the “Model Results” section. Information on previewing other plots and tables, tagging them, and generating a submission-ready List of Tables and Figures report is also available in that same section.

To access Darwin Reporter in Pirana, select a Darwin Search model that has results and click icon_modelresults.

R-Darwin Reporter pkgdown documentation is available here.

Prior to running Darwin Reporter

Darwin Reporter requires installation of the Certara.DarwinReporter R package (see “Prerequisites” in the Darwin section of “Configuration Settings”.

Additionally, $TABLE statements must first be added to the model using the Template Extras page. In the following example $TABLE statements, the third line corresponds to categorical covariate names, and fourth line to continuous covariate names. Ensure that the covariates named in the statements match the covariates in the search (i.e., the covariate names in the statements must exist as column names in all candidate models).

$TABLE ID TIME MDV IPRED PRED WRES CWRES NOPRINT FILE=sdtab ONEHEADER

$TABLE ID ETAS(1:LAST) NOPRINT FILE=patab NOPRINT ONEHEADER

$TABLE ID WT CLCR NOPRINT FILE=cotab NOPRINT ONEHEADER

$TABLE ID SEX NOPRINT FILE=catab NOPRINT ONEHEADER

For a description of the Templates Extras page, see “Template extras” (if you are using the legacy interface, see “Template extras”).

Note:    Darwin Reporter does not work for exhaustive searches, as it depends on key models (which are not present in the results of exhaustive searches).


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