Darwin (legacy) options for NONMEM models

This section describes the legacy UI for setting up a Darwin Search using NONMEM models. The legacy UI is accessed from Pirana using the shortcut keys Ctrl + Shft + N when drwn is chosen from the extension pulldown. (For a description of the JavaScript Application, see “Darwin (JS) options for NONMEM models”.)

The options for a Darwin search are grouped into categories that are displayed in the hierarchical tree on the left side of the Darwin Search properties window. The options available within each category are described in the following sections.

General

Data

Model template

Template extras

Sigmas

Downhill step properties

Omega search

Penalties

Postprocessing

Directories

GA setup

PSO setup

Model cache

Custom options

Validation of entries in the Darwin Search properties window occurs on all the pages. If there are any invalid fields, that field, as well as the page name in the tree on the left, will be highlighted in light red.

When the Save button is pressed, a .drwn file of the Darwin settings for the NONMEM model search.


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