The Loo-Riegelman object is a two-compartment IV-bolus model that uses deconvolution to estimate the fraction of drug absorption. The model also generates AUC and rate of absorption values. This deconvolution model is best used to calculate the absorption kinetics of intravenously administered drugs.
For drugs that are administered through methods other than IV-bolus, such as oral or transdermal methods, it is preferable to use the Deconvolution Object to evaluate drug release and absorption.
Use one of the following to add the object to a Workflow:
Right-click menu for a Workflow object: New > IVIVC > Loo-Riegelman.
Main menu: Insert > IVIVC > Loo-Riegelman.
Right-click menu for a worksheet: Send To > IVIVC > Loo-Riegelman.
To view the object in its own window, select it in the Object Browser and double-click it or press ENTER. All instructions for setting up and execution are the same whether the object is viewed in its own window or in Phoenix view.
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