The Loo-Riegelman method requires initial estimates for the model parameters describing the two-compartment model that fits the IV data. Parameter estimates can be obtained by using PK model 7 to evaluate the data prior to using the Loo-Riegelman object. The default is to use an external worksheet. All K (fractional rate constant) values must be greater than zero.
None: Columns mapped to this context are not included in any analysis or output.
Subj/Sort: Categorical variable(s) identifying individual data profiles, such as subject ID. The sort variables selected in the Main Mappings panel are used as default column headings.
K10: Fractional rate constant for the central compartment.
K12: Fractional rate constant for the flow between the central compartment and a peripheral compartment.
K21: Fractional rate constant for the flow between the peripheral compartment and a central compartment.
Use the Rebuild button to reset the internal worksheet to its default state. The Parameters sorts dialog is displayed when Rebuild is clicked.
Parameters sorts dialog
The first time the Parameters panel is selected, Phoenix displays a dialog for selecting sort variables to use to create the internal dosing worksheet. This dialog is only displayed if sort keys are selected.
The Parameters sorts dialog uses the sort variables specified in the Main Mappings panel. By default all sort variables are selected.
Press OK to accept the default sort variables.
To select a subset of the sort variables, clear the checkbox beside the unwanted sort variable and press OK.
To choose new sort variables, press Rebuild in the Parameters panel. The Parameters panel is cleared and the Parameters sorts dialog is displayed again.
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