Phoenix Model examples

• Variations in models using Theophylline data

• Variations in models using Phenobarbital data

• Variations in Emax models

• Fitting PK and PD data and using a simulation run

• Variations in models using Propofol data

• Logistic regression modeling in Phoenix

• Graphically create a peripheral elimination model

• Model using logarithmic concentration values (Lyon dataset)

• Creating a two dose point model for intravenous and oral data

• Covariate modeling with the PK01 dataset

• Using a linked indirect response model

• Simple PK population analysis using QRPEM

• Three category multinomial model with a covariate

• Exploring Event, Count, and LL Statements

• An example of individual modeling with Phoenix model

• Modeling circadian rhythm, inter-occasion variability, and two epsilons

Completed projects for most of these examples are available for reference in …\Examples\NLME. You can save a copy of the Examples directory (installed with Phoenix) to your Phoenix project directory via the Project Settings in the Phoenix Preferences dialog.

Within this directory there are other projects that illustrate one or more aspects of modeling with the Phoenix NLME engines:

•QRPEM_with_time_varying_covariate.phxproj shows how to structure a QRPEM model with time-varying covariates so that QRPEM can run it.

•Remifen.phxproj uses a more complex well-known model that uses nonlinear covari­ates (“Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil. I. Model Development.” Minto, Charles F.; Schnider, Thomas W.; Egan, Tal­mage D.; Youngs, Elizabeth; Lemmens, Harry J.; Gambus, Pedro L.; Billard, Valene; Hoke, John F.; Moore, Katherine H.; Hermann, David J.; Muir, Keith T.; Mandema, Jaap W.; Shafer, Steven L. Anesthesiology, January 1997, 86(1): 10–23. Clinical Investigation). This model is restructured so that it can be solved with QRPEM.

Most Phoenix objects require the same basic steps for their use. However, there may be multiple paths to accomplishing a step (e.g., main menu, right-click menu, drag-and-drop, etc.).

 

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Last modified date:6/26/19

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