IVIVC Object

IVIVC Tools

Phoenix provides several models for computing correlations between InVitro drug properties, such as dissolution, and InVivo responses, such as fraction absorbed. This process is useful for predicting PK responses such as maximum concentration or area under the curve.

IVIVC Toolkit for Phoenix WinNonlin is a software tool that brings enhanced deconvolution methods, numerical convolution, dissolution, and correlation models, guided by an “IVIVC Wizard” to pharmacokineticists and formulators.

IVIVC object: Build and manipulate InVitro-InVivo Correlation (IVIVC) models.
Deconvolution: Evaluate drug absorption from time-concentration data, based on the unit impulse response.
Levy Plot Object: Comparing predicted and observed concentrations over time as a measure of correlation model fit.
Loo-Riegelman Object: Estimate drug absorption assuming a one-compartment (Wagner-Nelson) or two-compartment (Loo-Riegelman) PK model.
WagnerNelson Object: Estimate drug absorption assuming a one-compartment (Wagner-Nelson) or two-compartment (Loo-Riegelman) PK model.
Convolution: Estimate or verify PK profiles based on the unit impulse response function and expected absorption profile.
Sigmoidal and Dissolution models: Sigmoidal models, including Hill, Weibull, Double Weibull and Makoid-Banakar, for modeling dissolution.