Options for NCA analysis
Click in the Model Type cell and select the type from the menu (PLASMA (200-202) or URINE (210-212)) for each biological matrix.
In the Specify Analysis Variables section, select the variable to use for each item.
Note: If you set up concentration unit conversions via the Unit Conversion button, be sure to select the concentration column with the “Converted_” prefix. This column contains the concentration values in the specified units.
In the NCA Method section, click in the Calculation Method cell and select the method from the menu. Choose from:
Linear Log Trapezoidal: Uses the log trapezoidal rule after Cmax or after C0, if C0 > Cmax. Otherwise, the linear trapezoidal rule is used. If Cmax is not unique, then the first maximum is used. This method uses linear trapezoids before Tmax and log trapezoids after Tmax.
Linear Trapezoidal Linear Interpolation: (Default setting) Applies the linear trapezoidal rule to each pair of consecutive points in the dataset that have non-missing values and sums up these areas. This method uses linear trapezoids before and after Tmax.
Linear Up Log Down: The linear trapezoidal rule is used when concentration data is increasing, and the logarithmic trapezoidal rule is used when the concentration data is decreasing. This method uses linear trapezoids up and logarithmic trapezoids down before Tmax and linear trapezoids up and logarithmic trapezoids down after Tmax.
Linear Trapezoidal Linear/Log Interpolation: This method is the same as Linear Trapezoidal Linear Interpolation. It is used when a final time point, that is not in the dataset, is used for predictions. In that case, a final concentration value is inserted using the Linear Trapezoidal Linear Interpolation rule. The Linear Trapezoidal Linear/Log Interpolation rule is used if the final time point is after Cmax or after C0, if C0 > Cmax. If Cmax is not unique, then the first maximum is used. This method uses linear trapezoids before and after Tmax.
In the Compute Concentrations at Times field, enter a comma-separated list of times at which the corresponding concentration is to be calculated.
The Partial Area button can be used to set up Partial Areas.
The Unit Conversion button can be used to specify Unit Conversions for concentration and time variables.
The Carry Alongs button allows you to Identify carry alongs to include in the results.
Use the Reorder Columns button to move the columns around in the lower table (the MasterConcentration worksheet).
In the pop-up dialog, click and drag the column names to change the order.
After completing the reordering, press OK.
When finished with the specifications, press the Submit button.