NonParametric Superposition Object
In pharmacokinetics it is often desirable to predict the drug concentration in blood or plasma after multiple doses, based on concentration data from a single dose. This can be done by fitting the data to a compartmental model with some assumptions about the absorption rate of the drug. An alternative method is based on the principle of superposition, which does not assume any pharmacokinetic (PK) model.
Phoenix’s nonparametric superposition object is used to predict drug concentrations after multiple dosing at steady state, and is based on noncompartmental results describing single dose data. The predictions are based upon an accumulation ratio computed from the terminal slope (Lambda Z). The feature allows predictions from simple (the same dose given in a constant interval) or complicated dosing schedules. The results can be used to help design experiments or to predict outcomes of clinical trials when used in conjunction with the semicompartmental modeling function.
Use one of the following to add the object to a Workflow:
Right-click menu for a Workflow object:
New > NonCompartmental Analysis > Nonparametric Superposition.
Main menu:
Insert > NonCompartmental Analysis > Nonparametric Superposition.
Right-click menu for a worksheet:
Send To > NonCompartmental Analysis > Nonparametric Superposition.
To view the object in its own window, select it in the Object Browser and double-click it or press ENTER. All instructions for setting up and execution are the same whether the object is viewed in its own window or in Phoenix view.
User interface description
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