The Wagner-Nelson model is a one-compartment IV-bolus model that uses deconvolution to estimate the fraction of drug absorption. The model also generates AUCs and rate of absorption values. This deconvolution model is best used to calculate the absorption kinetics of intravenously administered drugs.
For drugs that are administered through methods other than IV-bolus, such as oral or transdermal methods, it is preferable to use the Deconvolution Object to evaluate drug release and absorption.
Use one of the following to add the object to a Workflow:
Right-click menu for a Workflow object: New > IVIVC > Wagner-Nelson
Main menu: Insert > IVIVC > Wagner-Nelson.
Right-click menu for a worksheet: Send To > IVIVC > Wagner-Nelson.
To view the object in its own window, select it in the Object Browser and double-click it or press ENTER. All instructions for setting up and execution are the same whether the object is viewed in its own window or in Phoenix view.
The user interface for Wagner-Nelson is the same as that for Loo-Riegelman, except that Loo-Riegelman has an additional Parameters panel. Click the following to view the interface description in the “Loo-Riegelman” section.
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