Semicompartmental Modeling Object

Semicompartmental modeling was proposed by Kowalski and Karim (1995) for modeling the temporal aspects of the pharmacokinetic-pharmacodynamic relationship of drugs. Their model was based on the effect-site link model of Sheiner, Stanski, Vozeh, Miller and Ham (1979) to estimate effect-site concentration C_e, but uses a piecewise linear model for plasma concentration C_p rather than specifying a PK model for C_p. The potential advantage of this approach is reducing the effect of model misspecification for C_p when the underlying PK model is unknown.

Use one of the following to add the object to a Workflow:

Right-click menu for a Workflow object:
New > NonCompartmental Analysis > Semicompartmental Modeling.

Main menu:
Insert > NonCompartmental Analysis > Semicompartmental Modeling.

Right-click menu for a worksheet:
Send To > NonCompartmental Analysis > Semicompartmental Modeling.

To view the object in its own window, select it in the Object Browser and double-click it or press ENTER. All instructions for setting up and execution are the same whether the object is viewed in its own window or in Phoenix view.

User interface description

– Main Mappings panel

– Options tab

– Plots tab (See the description in the “Plots tab” section of the NCA documentation.)

Results

Semicompartmental calculations

Semicompartmental model example