Pharmacometrics Modeling Language

The Pharmacometrics Modeling Language (PML) supports specification of input and/or output data, trial-related settings such as dosing and treatment sequence, as well as flexible model definitions for PK/PD and general NLME modeling including survival analysis and modeling of categorical responses.

PML includes the needed structures for seamless integration of modeling with trial simulation and related analyses. It draws on established practices in R and NONMEM, making it easy to use when familiar with these software packages.

Familiarity with C++ and R syntax, conventions, and concepts is assumed.

More information is available for the following topics:

Modeling Project Files

Modeling Syntax

Supported Math Functions

Supported Special Functions

Closed-Form

Matrix Exponent

Supported Statements

Supported Operators

Running NLME Engines in Command Line Mode

PML examples