Phoenix Installation and Licensing
This section contains installation instructions and licensing information for the Phoenix platform and its modules, such as Phoenix NLME, the IVIVC Toolkit. The generic term Phoenix is used to simplify terminology.
System and hardware requirements
Post-installation considerations
Silent installation of Phoenix
Phoenix 64-bit versus 32-bit version
Testing the Phoenix installation
Test installation of Phoenix NLME
System and hardware requirements
Phoenix is a software platform built on the Microsoft .NET 4.7 framework. It uses the MinGW (Minimalist GNU for Windows) compiler to create PML (Pharmacometrics Modeling Language) models. Phoenix also uses Microsoft MPI to allow usage of multiple CPUs and CPU cores. All software prerequisites needed to use basic Phoenix functions are included in the Phoenix installation file. Extended Phoenix functions have additional software requirements.
Phoenix NLME-specific information
GNU compilers are 64-bit version 8.4.0 and the MPI version is 10.1.
Phoenix NLME only works on 64-bit systems.
NLME jobs can be executed on remote Linux hosts and Torque/SGE/LSF/SLURM grids from a Phoenix Windows installation.
If user accounts have limitations in executing command prompt commands, users will not able to execute NLME objects. The Prevent access to the Command Prompt policy for users must be changed from Enabled to Disabled.
Required software
Windows® Installer 3.1 can be downloaded through the Microsoft Update service or by downloading the Windows Installer 3.1 redistributable from the Microsoft download page.
A PDF reader, such as Adobe Reader, must be installed to access PDF files of various software documents, such as the Validation Suite report.
Compatibility with operating system versions
Phoenix is compatible with the following desktop operating system versions with the English (United States), Kanji (Japan), French (France), Spanish (Spain), German (Germany), or Simplified Chinese (China) language packs and with a Regional Options setting of English (United States):
Windows 10 (64-bit) version 1607 or greater, using a keyboard and mouse, Professional edition
*Phoenix NLME only works on 64-bit systems.
Phoenix is compatible with the following server operating system versions (for direct access or for access via a desktop with a terminal server application), with English (United States) operating system/language pack and Regional Options setting of English (United States):
Windows Server 2016
Windows Server 2019
Note: Phoenix is a desktop application that requires isolated resources to perform optimally. If you wish to deploy this desktop application in an enterprise type fashion, such as through Citrix, it is important that it be done in a manner that will isolate the recommended amount of resources to each user, such as through a VDI (virtual desktop infrastructure). Publishing Phoenix from a shared resource sever with multiple users is not recommended.
Phoenix is not supported on any cloud environments such as Azure, AWS, etc.
Compatible third-party software
Third-party tools that are to be used as plug-ins need to be installed on the server. The following third-party software programs are compatible with Phoenix.
Microsoft Office 2013, 2016, 2019 local installation and usage of Office 365 (32 and 64-bit).
Web version of Office 365 is not compatible with Phoenix for the tools that use Office.
SAS: versions up to and including 9.4 (32 and 64-bit)
NONMEM: 7.3, 7.4, and 7.5 (32 and 64-bit)
SigmaPlot as a third-party tool: 11.1 through 12.5
SigmaPlot as used by AutoPilot Toolkit 2.x for Phoenix: 11.1, 11.2, 12.2, 12.3, and 12.5
R for the R object and for Linux Grid computing: versions up to and including 4.2.3
R for Windows MPI-cluster processing for NLME: R 4.2.3.
PsN: versions up to and including 5.3.0 (only with the operating system version(s) and NONMEM version(s) with which each PsN version is compatible).
Note: PsN 3.4.2 and 3.6.7 are not compatible with server operating system versions or with German, Spanish, or Chinese language operating system versions/language packs.
See also the “Phoenix 64-bit versus 32-bit version” section.
Note: When Phoenix is installed and configured to run on a Windows operating system version where its Regional Language settings are not US English, SAS and SigmaPlot objects cannot be executed.
Compatible Certara software
Phoenix can be installed on the same computer with other current Certara software products.
It is not guaranteed that a project created with a newer version of Phoenix can successfully load on older versions of Phoenix. The system will warn the user if the project cannot be loaded. The opposite (backwards compatibility) is guaranteed, although, in some cases, settings or models are automatically updated to new options. Warnings are given when these automatic updates occur and the user should review the loaded settings and model.
Note: Newer versions of Phoenix NLME might fail when they are executed on a grid/remote Linux system that has older versions of Certara.NLME8 installed. Check that the version of the R library package Certara.NLME8 on the remote host is the same as the package distributed with the Phoenix version you are installing and upgrade, if necessary (see the “Job control for parallel and remote execution” section in the NLME documentation for instructions).
Hardware requirements
Processor
Minimum Requirement: Intel i5 processor 3 GHz
Recommended*: Intel i7 processor 4 GHz
RAM
Minimum Requirement: 8 GB of RAM
Recommended*: 16 GB of RAM
Internal Storage Device
Minimum Requirement: 1 GB 7200 RPM Magnetic HD
Recommended*: 1 GB SSD
*Especially for large datasets and large projects.
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