Phoenix provides several models for computing correlations between in vitro drug properties (e.g., dissolution) and in vivo responses (e.g., fraction absorbed). This process is useful for predicting PK responses such as maximum concentration or area under the curve.
IVIVC Toolkit brings enhanced deconvolution methods, numerical convolution, dissolution, and correlation models, guided by an “IVIVC Wizard” to pharmacokineticists and formulators.
IVIVC Object: Build and manipulate InVitro-InVivo Correlation (IVIVC) models.
Deconvolution Object: Evaluate drug absorption from time-concentration data, based on the unit impulse response.
Levy Plot: Compare predicted and observed concentrations over time as a measure of correlation model fit.
Loo-Riegelman: Estimate drug absorption assuming a one-compartment (Wagner-Nelson) or two-compartment (Loo-Riegelman) PK model.
Wagner-Nelson: Estimate drug absorption assuming a one-compartment (Wagner-Nelson) or two-compartment (Loo-Riegelman) PK model.
Convolution Object: Estimate or verify PK profiles based on the unit impulse response function and expected absorption profile.
Sigmoidal and Dissolution models: Sigmoidal models, including Hill, Weibull, Double Weibull and Makoid-Banakar, for modeling dissolution.
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