NCA user interface

NC A

Phoenix's noncompartmental analysis (NCA) engine computes derived measurements from raw data by using methods appropriate for either serially- or sparsely-sampled data. Phoenix provides the following NCA models for different types of input data:

200 Plasma/blood data type, extravascular dose type, requires constants for time of last dose and dose interval (Tau)^a

201 Plasma/blood data type, IV Bolus dose type, requires constants for time of last dose and dose interval (Tau)^a

202 Plasma/blood data type, constant infusion dose type, requires constants for length of infusion, time of last dose, dose interval (Tau)^a

210 Urine data type, extravascular dose type, requires constants for time of last dose

211 Urine data type, IV Bolus dose type, requires constant for time of last dose

212 Urine data type, constant infusion dose type, requires constant for time of last dose

220 Drug effect data type, any dose type, requires constants for time, baseline effect, and threshold (optional)

^aTau is required for steady-state data only.

Models 200–202 can be used for either single-dose or steady-state data. For steady-state data, the computation assumes equal dosing intervals (Tau) for each profile, and that the data are from a “final” dose given at steady-state.

Models 210–212 (urine concentrations) assume single-dose data, and the final parameters do not depend on the dose type.

The plasma and urine models support rich datasets as well as sparsely-sampled studies such as toxicokinetic studies. The drug effect model is for analysis of slope, height, areas, and moments in richly-sampled time-effect data.

Use one of the following to add the object to a Workflow:

Right-click menu for a Workflow object: New > NonCompartmental Analysis > NCA.
Main menu: Insert > NonCompartmental Analysis > NCA.
Right-click menu for a worksheet: Send To > NonCompartmental Analysis > NCA.

Note:To view the object in its own window, select it in the Object Browser and double-click it or press ENTER. All instructions for setting up and execution are the same whether the object is viewed in its own window or in Phoenix view.

This section contains information on the following topics:

NCA user interface description
Results
NCA computation rules
NCA parameter formulas
NCA examples