AutoPilot Toolkit business rules

The following table summarizes the business rules that set formats and options for calculations and output in AutoPilot Toolkit. For each rule the table indicates whether the rule is approved for worksheet and graph output and whether the user can activate/deactivate or modify the rule on a run-by-run basis. For details see the descriptions for each rule listed after the AutoPilot Toolkit Business Rules table.

Business rules
Rule and page number for details	Tables	Graphs	Run-specific	Enable/Disable; default selection
General
Context-sensitive footnotes	Yes	Yes	No	Yes; disabled
Managing footnotes	Yes	Yes	No
PK parameter percent-extrapolated threshold •Calculation of summary values •Footnote	Yes Yes	Yes No	No No	Yes; enabled
PK parameter Rsq adjusted threshold •Calculation of summary values •Footnote	Yes Yes	Yes No	No No	Yes; enabled
LOQ replacement •Calculation of summary values •Footnote	Yes Yes	Yes No	No No	Yes; some enabled
Matrix mapping	Yes	Yes	No	Yes; enabled
Summary statistics display for small sample sizes (“Summary stat calculation criteria”)	Yes	Yes	No	No; admin can set defaults
Summary statistics based on % threshold (“Summary stat calculation criteria”)	Yes	Yes	No	No; admin can set defaults
Individual values of zero treated as missing (“Summary stat calculation criteria”)	Yes	Yes	No	No; admin can set defaults
Exclusions	Yes	Yes	Yes	Yes; enabled
Tables
General business rules	Yes	No	Yes Tables only; all footnotes on each split	No
Missing references in WinNonlin	Yes	No	No	Yes; enabled
Intext Table Template tab	Yes	No	No	No
Display of different sample sizes in intext tables	Yes	No	No	Yes; enabled
Significance level display in statistical tables	Yes	No	No	Yes; enabled
Footnote about model time	Yes	No	No	Yes; enabled
RNT predose replacement	Yes	Yes	Yes, set LOQ value only	Yes; disabled
Display analyte and matrix information	Yes	Yes	Yes
Time deviations	Yes	No	No	No
Multiple analyte handling	Yes	Yes
Graphs
Time scale algorithm	No	Yes	No	Yes; enabled
Categorical PK parameter graph X-axis split/offset	No	Yes	Yes	No
Display analyte and matrix information	Yes	Yes	Yes	No; admin can set defaults
Axis starting points •Display negative scale for X-axis/Y-axis •Force X-axis/Y-axis to start at zero	No No	Yes Yes	No No	No
Multiple analyte handling	Yes	Yes
Suppression of summary values below LOQ	No	Yes	Yes