Table

  1. Click Add Table + to include extra results tables that contain user-specified output.

  2. Enter a name in the Table Name column.

  3. All model variables, including stparms, fixefs, secondary, and freeform assigned variables, can be added as output in the table.

    Information in any of the following table columns acts as a trigger and will cause the rows in the results table to change based on the trigger information entered. If no trigger information is specified, then the number of rows appearing in the table remains the same as the number of rows in the input datasets.

  4. In the Times column, enter sampling times to include in the tables. For example, 0.1, 1, 5, 12. A row is generated in the output table for each time.

    Additionally, a sequence statement like “seq(0,20,1)” can be used to convey that the times to out­put in the table should be from zero to 20 by 1 unit of time (e.g., 0, 1, 2, 3, …, 20). The first argu­ment in the seq statement is the starting time point, the second argument is the last time point, and the third argument indicates the time increments.

  5. In the When Covariate Set column, enter the covariates used, if any. For example, age, weight, gender. A row is generated in the output table at any time at which the specified covariate value is set (not missing).

  6. In the When Dose column, enter the dose point to include in the table. For example, Aa or A1. A row is generated in the output table at any time at which a dose is administered to the specified compartment, if dosing data is provided in the input source or a dosing worksheet.

  7. In the When Observe column, enter any observations to include in the table. For example, CObs or EObs. A row is generated in the output table at any time at which the specified observation is made.

  8. In the Variable column, enter any additional variables not applicable in the other fields (separated by commas). A column is added to the table for each variable specified in the list.

    For example, to capture concentration C and a secondary parameter called C2 at each observa­tion of concentration (CObs) and at time 7.5 enter 7.5 in the Times column, CObs in the When Observe column, and C and C2 in the Variable column.

    The Variable column can also be used to get population prediction (PRED). This is done through a special function “pred” with its arguments set to be some observed variable names. For example, to capture PRED corresponding to the observed variables, CObs and EObs, at times 1 and 4 as well as at the observation times for CObs, enter 1, 4 in the Times column, CObs in the When Observe column, and pred(CObs, EObs) in the Variable column.

  9. Check the boxes for TAD, IRES, Weight, and IWRES to include these values in the output table. For IRES, Weight, and IWRES, specify an observation for the When observe option to make the checkboxes become available.

  10. Note:The variable names are case sensitive. If the table is not produced as expected, check the case of the variable names in the table specification.

  11. Click the  button to delete the corresponding table.

Simple run table use

An example use of the Table option in Simple mode is to simulate the effect of adding a number of infusions of 50 dose units infused at a rate of 100 every 72 time units. Select the ADDL option button in the Input Options panel (see “Setting Model Input Options”) and click +. Then enter values for the dosing regimen as shown below:

For Dose Point, enter 50 in the field and select Infusion from the pulldown.
For Amount, select Constant from the pulldown and enter 50 in the field.
For Rate, select Constant from the pulldown and enter 100 in the field.
For Delta Time, select Constant from the pulldown and enter 72 in the field.

In the Model Executor window, the Maximum Number of Iterations should be set to zero so that the estimates are fixed. The Simple mode Table can be specified to output the times desired to see simu­lated concentrations. The request outlined below is to output times from zero to 600 in increments of 0.5. Note that requesting the variable “C” indicates that predicted concentration values (C) should be recorded at the times requested, when doses are added to the amount in the central compartment (A1), and when concentrations are observed (CObs).

Enter seq(0,600,0.5) in the Times column.
Enter A1 in the When Dose column.
Enter CObs in the When Observe column.
Enter C in the Variable column.


Last modified date:12/17/20
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