Emax model parameters are grouped into categories:
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Residual error models
See the PK “Residual Error Model” section for descriptions of the parameters
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Use the checkboxes to build the structural model equation.
–Baseline: Check if the model has a baseline response. A new parameter, E0, is added to the baseline response and the Fractional checkbox is made available.
–Fractional: Check if the Emax model is fractional.Selecting this option modifies the E0 equation statement.
–Inhibitory: Check if the Emax model is inhibitory.The structural parameters EC50 and Emax change to IC50 (concentration producing 50% of maximal inhibition) and E0 (baseline effect).
–Sigmoid: Check if the Emax model is sigmoidal.A shape parameter, Gam, is added.
