Linearization Method and the Resulting Algorithms

The linearization method involves linearization of f in Eqtn_1_1_8f_LapStatisticalModel (discussed in “Review of Laplacian-Approximation Formulation”) around thetai_xii and then replacing rtijthetaibeta with rtijxiibeta. Two values are often chosen for the linearization point xii:

xiimu (that is, etai = 0), i = 1, 2,..., NSUB 
The resulting algorithm is the first-order (FO) method.

xii_thetacaretimode,the conditional modes obtained using the current population parameter estimates, i = 1, 2,..., NSUB.
The resulting algorithm is the first-order conditional estimation method (FOCE method).

For the linearization method, Yij is approximated as

Eqtn_1_1_9_LinearizationMethodY

for j = 1, 2,..., mi, i = 1, 2,..., NSUB.

Due to the normal and independent assumptions on Thetai and eij, Yij is approximately normally distributed with mean and variance, respectively given by

Eqtn_1_1_10_Mean

and

Eqtn_1_1_11_Variance

Thus, the logarithm of the marginal PDF is approximated as

Eqtn_1_1_12_MarginalPDF

where

Eqtn_1_1_13_MarginalPDFWhere

Note that the approximate marginal PDF obtained above depends on the assumption that eij is i.i.d. normally distributed. Hence, the linearization methods are only applicable to normal/Gaussian data.

For simple problems, the linearization method is usually faster than the other approximation methods, and the estimates are usually accurate. However, if the model is highly nonlinear, then the linearization method may provide a poor approximation to the marginal PDF, and hence the estimates obtained may be far less accurate.


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