Output from validating the correlation will have a prefix of “Validation.”
Worksheets
Average Vivo.Statistics: Summary statistics for in vivo data profiles.
Avg PE Stats: Summary statistics for percent error calculations.
Baseline Stats: Observed summary statistics.
Conv.Exponential Terms: Specified exponential terms and corresponding values for convolution.
Conv.Results: Convolution results.
Model Sim Vitro: Model simulated in vitro data.
Model Sim Vivo: Model simulated in vivo data.
Predicted Stats: Predicted summary statistics.
Validation Errors: Validation percent error and ratio calculation results.
The following worksheets will have a prefix of “Validation.Corr Sim.” Refer to the Phoenix WinNonlin Least-Squares Regression Models “Worksheet output” section for descriptions of most of these worksheets.
Correlation Matrix
Diagnostics
Dosing Used
Eigenvalues
Final Parameters
Final Parameters Pivoted
Initial Estimates
Partial Derivatives
Predicted Data
Stacked Partial Derivatives
Summary Table
User Defined Settings
VarianceCovariance Matrix
Two sets of the following worksheets are generated and will have a prefix of “Validation.Observed Baseline Nca.” or “Validation.Predicted PK Nca.” Refer to the Phoenix WinNonlin NCA “Results” section for descriptions of most of these worksheets.
Dosing Used
Exclusions
Final Parameters
Final Parameters Pivoted
Partial Areas
Plot Titles
Slopes Settings
Summary Table
Therapeutic Response
User Defined Computed Y
User Defined Parameters
User Defined Parameters Pivoted
Plots
The following plots will have a prefix of “Validation.” Refer to the Phoenix WinNonlin Least-Squares Regression Models “Plot output” section for descriptions of most of these plots.
Observed Y and Predicted Y vs X: Separate plots are generated for Corr Sim, Observed Baseline Nca, and Predicted PK Nca.
Partial Derivatives Plot
Predicted Y vs X
Weighted Residual Y vs X
Val Conv Out: Convolution plot of both observed and predicted data (each tab shows plot for one formulation).
Text Files
Average Vivo Settings: Mappings and settings for averaging in vivo data.
Baseline Stats: Mappings and settings for baseline statistics.
IVIVC.Validation: Mappings and settings for filtering columns prior to calculating validation errors.
Core output: Settings, summary table, and final parameters. A separate file is generated for Corr Sim, Observed Baseline Nca, and Predicted PK Nca.
Settings: Mappings and option settings. A separate file is generated for Conv, Corr Sim, Observed Baseline Nca, and Predicted PK Nca.Core output: One for Corr Sim, Observed Baseline Nca, and Predicted PK Nca.
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