To provide smoothing, fit the dissolution data to a sigmoidal dissolution model. The Prediction tab generates a table of prediction errors for AUC and Cmax by comparing predicted data for test formulations mapped to the Prediction Data mapping panel to the target formulation identified on the InVitro Formulation mapping panel.
The options available in this tab are the same as those in the InVitro settings tab, with the exception of the following:
Target Formulation: Select a target formulation to use as the comparator in predictions. Only one formulation can be selected in the menu.
Predict PK: Generate the prediction error worksheets. Worksheets are created for AUC, Cmax and other NCA parameters. This is done by comparing test formulations to the target formulation identified on the InVivo Data mapping panel. Typical NCA output like final parameters and summary table worksheets are created in the Results tab.
Note: Even if a prediction is not being done, the Target Formulation option should be set in order to use output from IVIVC downstream. If it is not set, it will prevent IVIVC from passing verification, which will prevent use of output in other objects.