Output from PK prediction will have a prefix of “Prediction.”
Worksheets
Baseline Stats: Observed summary statistics.
Conv.Exponential Terms: Specified exponential terms and corresponding values for convolution.
Conv.Results: Convolution results.
Model Sim Vitro: Model simulated in vitro input.
Model Sim Vivo: Model simulated in vivo input.
Pred Stats Out: Prediction summary statistics, stacked.
Predicted Stats: Predicted summary statistics for each parameter.
Prediction Errors: Prediction percent error and ratio calculation results.
The following worksheets will have a prefix of “Prediction.Corr Sim.” Refer to the Phoenix WinNonlin Least-Squares Regression Models “Worksheet output” section for descriptions of most of these worksheets.
Correlation Matrix
Diagnostics
Eigenvalues
Dosing Used
Final Parameters
Final Parameters Pivoted
Initial Estimates
Partial Derivatives
Predicted Data
Stacked Partial Derivatives
Summary Table
User Defined Settings
Variance Covariance Matrix
Two sets of the following worksheets are generated and will have a prefix of “Validation.Observed Baseline Nca.” or “Validation.Predicted PK Nca.” Refer to the Phoenix WinNonlin NCA “Results” section for descriptions of most of these worksheets.
Dosing Used
Exclusions
Final Parameters
Final Parameters Pivoted
Partial Areas
Plot Titles
Slopes Settings
Summary Table
Therapeutic Response
User Defined Computed Y
User Defined Parameters
User Defined Parameters Pivoted
Plots
The following plots will have a prefix of “Prediction.” Refer to the Phoenix WinNonlin Least-Squares Regression Models “Plot output” section for descriptions of most of these plots.
Observed Y and Predicted Y vs X: Separate plots are generated for Corr Sim, Observed Baseline Nca, and Predicted PK Nca.
Partial Derivatives Plot
Predicted Y vs X
Weighted Residual Y vs X
Pred Conv Out: Convolution plot of both observed and predicted data (each tab shows plot for one formulation).
Text Files
IVIVC.Prediction.Prediction.Calculate Errors Calculations.PEC: Mappings and option settings for percent error calculations.
Core output: Settings, summary table, and final parameters. A separate file is generated for Corr Sim, Observed Baseline Nca, and Predicted PK Nca.
Settings: Mappings and option settings. A separate file is generated for Conv, Corr Sim, Observed Baseline Nca, and Predicted PK Nca.
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