Deconvolution is used to evaluate in vivo drug release and delivery when data from a known drug input are available. Depending upon the type of reference input information available, the drug transport evaluated will be either a simple in vivo drug release such as gastro-intestinal release, or a composite form, typically consisting of an in vivo release followed by a drug delivery to the general systemic circulation.
One common deconvolution application is the evaluation of drug release and drug absorption from orally administered drug formulations. In this case, the bioavailability of the drug is evaluated if the reference formulation uses vascular drug input. Similarly, gastro-intestinal release is evaluated if the reference formulation is delivered orally. However, the Deconvolution object can also be used for other types of delivery, including transdermal or implant drug release and delivery.
Deconvolution provides automatic calculation of the drug input. It also can direct the analysis to investigate issues of special interest through different parameter settings and program input.
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