PK/Indirect model options

The following options are for the Indirect portion of the PK/Indirect model. Options for the PK portion of the model are the same as those listed under “PK model options”.

In the Indirect menu, select the indirect model type:

Stim. Limited (limited stimulation of input)
Stim. Infinite (infinite stimulation of input)
Inhib. Limited (limited inhibition of input)
Inhib. Inverse (inverse inhibition of input)
Stim. Linear (linear stimulation of input)
Stim. Log Linear (logarithmic and linear stimulation of input)

Use the Indirect menu options to select a model in which the response formation (build-up) or degradation (loss) is stimulated or inhibited by increased concentrations. The default response setting is the build-up of the response, or the production of the response.

Click Build-up to change the response setting to a Loss, or fractional turnover rate, of response.

This constructs a model where the degradation of response is concentration dependent. For example, Loss statement with limited stimulation:
deriv(E = Kin – Kout*(1+Emax*C/(C+EC50))*E)
Click Loss to change the response setting back to Build-up of the response.

This constructs a model where the formation of response is concentration dependent. For example, Buildup statement with limited stimulation:
deriv(E = Kin*(1+Emax*C/(C+EC50)) – Kout*E)
Click no Exponent/Exponent to toggle between adding and removing an exponent to/from the concentration dependent response build-up/loss term. For example, build-up with limited stimulation and exponent.
deriv(E = Kin*(1+Emax*C^gam/(C^gam+EC50^gam)) – Kout*E)
The Residual Error model options for the PK model and the Indirect model are the same as the PK model options and Emax model options.