Dosing panel

The Dosing panel is useful for PK or PK/PD models in the case where the dosing information and observations are in different files.

None: Data types mapped to this context are not included in any analysis or output.

Sort: Up to 5 additional study variables used to sort the output. A separate analysis is performed for each unique combination of sort variable values. Do not use sort values when pooling data. See “A note about Pooled data” for more information.

ID: Up to 5 categorical variable(s) identifying individual data profiles, such as subject ID and treatment in a crossover study. Only available in Population modeling.

Note:If the number of variables mapped to Sort and ID exceeds five, only the first five will be used. In cases such as this, it is suggested to use less Sort/ID variables or merge them accordingly when possible.

A1: The amount administered to Compartment 1 for Intravenous (Micro, Clearance, or Macro). Used if Intravenous is selected in the Absorption menu (Structure tab).

A1 Rate/A1 Duration: The rate of infusion for Intravenous or Infusion (Micro, Clearance, or Macro; A Rate for Macro1). The column A1 Rate appears in the Mappings panel when the Infusions possible? option is checked in the Structure tab. The column A1 Duration appears when the Infusions possible? option is checked and then the Duration? option is checked.

Aa: The amount administered to the absorption compartment for Extravascular (Micro, Clearance, Macro or Macro1). Used if Extravascular is selected in the Absorption menu (Structure tab).

Aa Rate/Aa Duration: The rate/duration of drug delivery when using an extravascular delivery method. The column Aa Rate appears when the Infusions possible? option is checked in the Structure tab. The column Aa Duration appears when Infusions possible? is checked and then Duration? is checked.

Time: The time of dose administration. See “Time and date variable formatting” for acceptable formatting.

Selecting different input options in the Input Options tab adds the following extra columns in the Dosing panel for each model.

MDV: Appears when MDV is checked in the Input Options tab. Missing dependent variable flag could be mapped. See the MDV description under Main Mappings panel for more information.

Steady State: Appears when Steady State is checked in the Input Options tab. Used if the model reaches a steady state. See “More on Steady State” for more details.

ADDL: Appears when ADDL is checked in the Input Options tab. Used if additional identical doses are included in the dataset. See “More on ADDL” for more details.

Date: Appears when Date is checked in the Input Options tab. Year, month, and day are in a pre-specified format. See “Time and date variable formatting” for acceptable formatting.

Note:If an internal worksheet is used, input for all values of the sort variables is required.

Note:Rebuild an internal dosing worksheet when changing a model from individual to population, or vice versa, and changing between Sort and ID mapping. Otherwise, it can cause a verification error upon execution.