Most integration settings are not required to work with Pirana. Many program locations are only used to create easy links to the software from within Pirana.
Select File > Settings and choose Software Integration in the left list.
Enter the path to the appropriate executable or configuration file for the extension.
Use ... to navigate to a file or use 
to select a folder.
The following are important to set correctly to work with Pirana easily:
R location: Pirana uses R and Xpose4 to generate graphs.
Location of R GUI (if available).
Spreadsheet location (i.e., Excel, Numeric, etc.): Enables viewing of CSV files.
Code/text editor: This editor is used to edit models or scripts.
PDF file viewer: Enables viewing of the many graphics that are created as PDF files.
Expand Software Integration and select a software program name.
API key — Obtained during the Certara.IntegralR setup. The API key stores your Certara Admin credential, which are needed to interact with the Integral repository (refer to https://certara.github.io/R-Integral/articles/overview.html).
Repo URL — URL for your Integral repository.
Default upload reason — Enter text to use as a default reason when uploading to Integral. This reason is used if the Use last reason checkbox is unchecked.
Upload extensions — Enter a comma-separated list of extensions on which to filter the list of files available for uploading (in the Upload dialog).
Request timeout — The REST client timeout (seconds). This value may need to be increased if connections are poor or when uploading files that are 50-100 MB or more.
Maximum file size — The maximum file size Pirana will load from Integral.
Use last upload reason — Check to save the reason entered in the Upload dialog and use it for the next upload to Integral. Uncheck to use the default reason.
Files must have extensions — Check to prevent uploading of files without extensions.
Create target folder if it doesn’t exist — Check to allow Pirana to create the target folder. If unchecked, a message is displayed if the target folder does not exist in the repo.
Clear folder history — Press to clear all stored target folders used for upload.
Check the Enable Pirana support for PsN box to edit PsN’s default parameter settings. These settings appear in the PsN command line field when you choose 
> Model diagnostics and select an option. Refer to the PsN documentation for details on specific parameters.
Changes made in this panel only affect options in the Run Xpose4 Commands dialog (Results > Xpose4 > Xpose4 GUI). The scripts included with Pirana are not affected.
Initialization commands — Commands for loading specific R libraries when executing R/Xpose4.
Hide console window until error in R-script — Check to display the console window only if there is a script error.
PDF/PNG /GIF arguments — Default plotting arguments for R printing devices.
Postscript arguments — Commands to execute at the end.
Show Stan functionality in Pirana — Check to display Stan functionality in Pirana’s UI.
Stan model file extension — Extension identifying Stan model files.
Folders to be added to LIBRARY_PATH / Folders to be added to PATH — Refer to the NMQual setup instructions for the folders to specify in these fields.
NMQUAL default run parameters — Parameters to set up the run environment.
NMQual installation path — Path to the NMQual folder.
Enable Pirana support for WFN — Check to enable editing of the WFN settings.
WFN startup parameters — Parameters for setting up the run environment.
NMBS parameters — NMBS command arguments to execute bootstrap NONMEM runs.
WFN.bat location — Path to the folder containing the WFN.bat file.