View_and_compare_parameter

View and compare parameter estimates

A list of parameter estimates is available in the Estimates tab in the right section of the Pirana window.

ParameterEstSingleRun

Through the use of brackets and color additional information is presented in the Estimates tab.

(RSE for parameters is shown in round brackets)

[Shrinkage for the random effects is shown in square brackets]

Parameters where the final gradients were zero have red text (NONMEM models only*)

Parameters were fixed have a gray background

Parameters where boundaries were encountered have a blue background

Parameters where the mean of eta-distribution was significantly different from zero include the etabar with a red background

*NLME does not generate gradient information so text will not be colored.

Using the Estimates tab toolbar, you can easily access the following tools and functionality:

– icon_paramestimates : Display the Parameter Estimates dialog, which gives a more detailed list of estimates.

– icon_R : Export the estimates using R.

– icon_genreport : Generate report.

– icon_shownmoutput : View the NM output file.

– icon_datainspector : Open dataset/output files in DataInspector

– icon_viewmatrix : View matrix. Select type of matrix from the pop-up menu (see “Matrices” for more information).

The more detailed Parameter Estimates dialog can be accessed using the any of the following methods:

– Click icon_paramestimates in the Pirana toolbar.

– Click icon_paramestimates in the Estimates tab toolbar.

– Select Results > Show/compare parameter estimates.

– Select View > Show parameter estimates.

– Right-click a selected model in the model overview list and choose Model > Parameter estimates from the menu.

ParameterEstSingleRunDetails

If multiple models/runs are selected when the Parameter Estimates dialog is opened, the parameter estimates for all selected runs are presented, side-by-side, facilitating comparison.

ParameterEstimatesMultipleRuns

The pull-down menu offers different choices for transforming the variances. Options include: Untransformed, (sqrt(OM^2), and (sqrt(exp(OM^2)-1).

ParameterEstSingleRunBottom

Check the exp(THETA) box to back transform thetas that have been log-transformed in model code.

Pirana will automatically back-transform when the parameter description includes the text “[log]”, e.g.,

     #THETA
     (0.,1.6,4.) ;KA [log]

From the dialog, convert results into CSV format, LaTeX, or HTML for reports or further analysis using the buttons along the bottom.

ParameterEstButtons