Power for 80-20 Rule

Power_80_20 in the output is the power to detect a difference in least square means equal to 20% of the reference least squares mean. Percent of Reference to Detect on the Options tab should be the default value of 20%, and the desired result is that Power_80_20 is greater than 0.8 or 80%. (See pg. 142–143 of Chow and Liu (2000).) In general:

PowerOfTest=1 – (probTypeIIError) = probRejectingH0, when H1 is true

Let mT and mR be the true (not observed) values of TestLSM and RefLSM. For this type of power calculation, for the no-transform case, the power is the probability of rejecting: H0(mT = mR) given H1:

|mTmR| = fractionToDetect(mR)

For ln-transform, and data already ln-transformed, this changes to:

|mT = –mR| = –ln(1– fractionToDetect)

and similarly for log10-transform and data already log10-transformed.

For the default fractionToDetect=0.2, the default a=0.05 (2*a=(100 – Confidence_Level) /100), with no transform on the data and mR > 0:

Power = Pr 

(rejecting H0 at the alpha level given the true difference in means = 0.2 x mR)

= Phoenix_UserDocs_Bioequivalence_Object_image3405

given |mTmR| = 0.2(mR)

Let:

Phoenix_UserDocs_Bioequivalence_Object_image3407

Then:

Power » 1 – [Pr(T > t1) – Pr(T > t2)]

where T has a central t distribution with df=Diff_DF. Note that the second probability may be negligible.

For ln-transform or data already ln-transformed, this changes to:

Phoenix_UserDocs_Bioequivalence_Object_image3409


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