PD output parameters in a PK-PD model

The output parameters for PD models in a linked PK/PD model differ from the parameters for PD models that are not linked. The following list shows the PD model parameters used in linked PK/PD models (estimated parameters in parentheses and secondary parameters in square brackets).

101 Simple Emax model (Emax, EC50, Ke0)

102 Simple Emax model with a baseline effect (Emax, EC50, E0, Ke0) [Rmax, F_Emax]

103 Inhibitory effect E0 model (E0, IC50, Ke0)

104 Inhibitory effect Imax model with a baseline effect (Imax, IC50, E0, Ke0) [Rmax, F_Emax]

105 Sigmoid Emax model (Emax, EC50, Gamma, Ke0)

106 Sigmoid Emax model with a baseline effect (Emax, ECe50, E0, Gamma, Ke0) [Rmax, F_Emax]

107 Inhibitory effect sigmoid E0 model (E0, IC50, Gamma, Ke0)

108 Inhibitory effect sigmoid Imax model with a baseline effect (Imax, IC50, E0, Gamma, Ke0) [Rmax, F_Emax]

Below are definitions for the estimated and secondary parameters.

Emax: Maximum drug effect.

Imax: Maximum drug inhibition.

EC₅₀: Concentration in plasma that achieves 50% of predicted maximum effect in an Emax model.

ECe₅₀: For effect compartment models, the concentration at the effect site that achieves 50% of predicted maximum effect in an Emax model.

IC₅₀: Drug concentration required to produce 50% of the maximal inhibition.

E₀: Baseline effect (effect at 0). In models 103 and 107, E0 could also be named Imax, the maximum drug inhibition.

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