Time_deviations_in_steady-state

Time deviations in steady-state data

When using steady-state data, Phoenix computes AUC_TAU from dose time to dose time+tau, based on the tau value set in the Dosing panel. However, in most studies, there are sampling time deviations. For example, if dose time=0 and tau=24, the last sample might be at 23.975 or 24.083 hours. In this instance, the program will estimate the AUC_TAU based on the estimated concentration at 24 hours, and not the concentration at the actual observation time. For steady state data, Cmax, Tmax, Cmin and Tmin are found using observations taken at or after the dose time but no later than dose time+tau.