Discrete_(plasma)_parameters_that_do_not_require_Lambda_Z

Discrete (plasma) parameters that do not require Lambda Z estimation

AUCall: Area under the curve from the time of dosing to the time of the last observation. If the last concentration is positive, AUClast=AUCall. Otherwise, AUCall will not be equal to AUClast, as it includes the additional area from the last measurable (positive) concentration down to zero or negative observations.

AUClast: Area under the curve from the time of dosing to the time of the last measurable (positive) concentration (Tlast).

AUClast_D: = AUClast/Dose

AUMClast: Area under the moment curve from the time of dosing to the last measurable (positive) concentration.

C0: Initial concentration. Given only for IV Bolus dosing. It is equal to the first observed concentration value if that value occurs at the dose time. Otherwise, it is estimated by back-extrapolating (see AUC_%Back_Ext below).

Clast: Observed concentration corresponding to Tlast.

Cmax: Maximum observed concentration, occurring at time Tmax, as defined below.

Cmax_D: = Cmax/Dose

Dose: Amount of last administered dose. This is assumed to be zero if not specified.

Dosing time: (Designated as ‘Time’ in the Dosing Used results.) Time of last administered dose. It is assumed to be zero unless otherwise specified. This parameter is used mainly with steady-state data, where input times may be coded as the time elapsed since the last dose (i.e., time resets to zero at the last dose), or the elapsed time since the time of the first dose.

MRTlast: Mean residence time from the time of dosing to the time of the last measurable concentration.

For non-infusion models: = AUMClast/AUClast

For infusion models: = (AUMClast/AUClast) – (Tinf/2)

where Tinf is the length of infusion.

No_points_lambda_z: Number of points used in computing Lambda Z. If Lambda Z cannot be estimated, this is set to zero.

N_Samples: The number of observations used in the analysis. It does not include missing or non-numeric observations, observations before dosing time, or interval observations where volume is zero, or points inserted by the engine (e.g., inserted at dosing time).

Tlag: Time of observation prior to the first observation with a measurable (positive) concentration. For discrete data (plasma), Tlag is only computed when the dosing type is extravascular.

Tlast: Time of last measurable (positive) observed concentration (missing if no positive data).

Tmax: Time of maximum observed concentration. For non-steady-state data, all data points used in the analysis are considered. If the maximum observed concentration is not unique, then the first maximum is used.