This example shows how to turn a single dose point model into a two dose point model using the graphical editor.
The data used in the cmt1ivpo dataset is from a simulated trial. The purpose of this example is to show how to use a dataset that contains multiple dosing routes with the Phoenix NLME GUI.
Note: The completed project (IVPO.phxproj) is available for reference in …\Examples\NLME.
Set up the Maximum Likelihood Models object
Create a new project called IVPO.
Import the dataset …\Examples\NLME\Supporting files\cmt1ivpo.dat.
Pres Finish in the File Import Wizard dialog.
Right-click the cmt1ivpo worksheet and select Send To > Modeling > Maximum Likelihood Models.
In the Structure tab of the Phoenix model, select Clearance from the Parameterization menu, if needed.
From the C (Continuous Observation) error model menu, select Multiplicative.
Keep the default value of 0.1 in the Stdev field.
Graphically edit the model
Press Edit as Graphical.
In the confirmation dialog, press Yes.
In the second confirmation dialog about not using the closed-form, press Yes.
Select Model in the Setup tab list, if needed.
Add an Absorption compartment by clicking 
in the Maximum Likelihood Models object toolbox.
Add a PK flow between the Absorption compartment Aa and the Central compartment C.
Click in the toolbox.
Click the first compartment of the flow, the Absorption compartment Aa.
Click the second compartment of the flow, the Central compartment C.
The PK flow is inserted between the two-compartments and is labeled K_Aa_C.
Select the Parameters > Fixed Effects sub-tab.
In the Initial column, type 0.2 as the initial estimate for tvCl.
Select the Random Effects sub-tab.
Type 0.1 in the fields for nV, nCl, and nK_Aa_C.
Map the model variables
Select Main in the Setup list.
Map the columns to the contexts as follows:
id to ID.
time to Time.
conc to CObs.
doseiv to A1.
dosepo to Aa.
Click 
(Execute icon) to execute the object.
Save and close the project
Select File > Save Project.
Press Save.
Select File > Close Project.
The project is saved and closed and Phoenix can be safely exited.
This concludes the two dose point model example.