The Therapeutic Response panel determines the time spent within a therapeutic range, and the AUC within the therapeutic range, by using the lower and upper therapeutic response values. For descriptions of how the NCA object handles therapeutic response data, see the “Therapeutic response” section.
Setting the therapeutic response values is optional for plasma (200–202) and urine (210–212) models. Setting the baseline is recommended for drug effect models (220). The Min Response and Max Response columns show the minimum and maximum concentrations, rates, or responses contained in the datasets.
Note: When entering or mapping the lower and upper therapeutic ranges of profiles in an NCA urine model, the rate of excretion must be entered or mapped.
None: Columns mapped to this context are not included in any analysis or output.
Sort: Categorical variable(s) identifying individual data profiles.
Lower (Plasma and Urine study) / Baseline (Drug Effect study): The lower concentration, rate, or response for defining the lower boundary of the target range. This is the lower effect value for each profile. It is required when an external worksheet is mapped. If not specified for the drug effect model, a baseline of zero is used.
Upper (Plasma and Urine study) / Threshold (Drug Effect): The upper concentration, rate, or response for defining the upper boundary of the target range.
Threshold is the effect value used to calculate additional times and areas. See the “Drug effect data model 220” section.
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