The start time, end time, and exclusions used in the calculation of Lambda Z for each profile are defined in the Slopes panel. Type the time points for each profile.
Below are usage instructions. For descriptions of how the NCA object determines Lambda Z or slope estimation settings, see the “Lambda Z or Slope Estimation settings” section.
Note: Any changes to the settings available in the Slopes panel also affect the Slopes Selector panel and vice versa.
Type the start and end time values in the Start Time and End Time columns for each profile.
Type excluded time points in the Exclusions column for each profile.
Exclude multiple time points for a profile by typing the time points in the same cell and separating the time points with a semicolon.
Use the Fit Method menu to specify the method.
If Best Fit is selected, Phoenix calculates the points for Lambda Z estimation.
If Time Range is selected, enter the start and end times for Lambda Z estimation.
To turn off Lambda Z or slope estimation for all profiles, select the Disable Curve Stripping checkbox in the Options tab. For more information see step 3 in the “Model settings” section.
The Slopes panel for the Drug Effect (220) model also includes options for the slope calculation method.
In the Lin/Log column, select Linear or Log to set the slope calculation method.
Use the same instructions listed above to select the start times, end times, and exclusions.