The Simple run option estimates the parameters for the specified model with the selected options and engine method. The Simple option is available for Population and Individual models and allows specifying additional optional output tables. For example, specify an output table whose rows represent instances where covariates are set, dose points receive a dose, or observables are observed.
With Simple selected as the Run Mode in the Run Options tab, press Add Table to include extra results tables that contain user-specified output.
Entering values in the newly displayed fields creates custom table output that is sorted on a per profile basis.
In the list of added tables above the Add Table button:
a. Check the box after the table identifier to view/modify the table settings for that table. (Only one table can be selected at a time.)
b. Enter a brief description of the custom output table in the field.
c. Click the X button to delete the corresponding table.
Press Structural Parameter to add the parameters defined in the Structural tab or stparm statement to the Variables field.
All model variables, including stparms, fixefs, secondary, and freeform assigned variables, can be added as output in the table.
Check the Keep source structure box to keep the number of rows appearing in the table the same as the number of rows in the input datasets. Below the checkbox, enter the covariates, doses, observations, and variables to include in the table.
Or
Uncheck the box to allow the rows in the results table to change based on the information entered for the following triggers:
For Times, enter sampling times to include in the tables. For example, 0.1, 1, 5, 12. A row is generated in the output table for each time.
Additionally, a sequence statement like “seq(0,20,1)” can be used to convey that the times to output in the table should be from zero to 20 by 1 unit of time (e.g., 0, 1, 2, 3, …, 20). The first argument in the seq statement is the starting time point, the second argument is the last time point, and the third argument indicates the time increments.
For When Covariate Set, enter the covariates used, if any. For example, age, weight, gender. A row is generated in the output table at any time at which the specified covariate value is set (not missing).
For When Dose, enter the dose point to include in the table. For example, Aa or A1. A row is generated in the output table at any time at which a dose is administered to the specified compartment, if dosing data is provided in the input source or a dosing worksheet.
For When Observe, enter any observations to include in the table. For example, CObs or EObs. A row is generated in the output table at any time at which the specified observation is made.
For Variable, enter any additional variables not applicable in the other fields (separated by commas). A column is added to the table for each variable specified in the list.
For example, to capture concentration C and a secondary parameter called C2 at each observation of concentration (CObs) and at time 7.5 enter 7.5 for Times, CObs for When Observe, and C, C2 for Variable.
Variable can also be used to get population prediction (PRED). This is done through a special function “pred” with its arguments set to be some observed variable names. For example, to capture PRED corresponding to the observed variables, CObs and EObs, at times 1 and 4 as well as at the observation times for CObs, enter 1, 4 for Times, CObs for When Observe, and pred(CObs, EObs) for Variable.
Check the boxes for TAD, IRES, Weight, and IWRES to include these values in the output table. For IRES, Weight, and IWRES, specify an observation for the When observe option to make the checkboxes become available.
Note: The variable names are case sensitive. If the table is not produced as expected, check the case of the variable names in the table specification.
Simple run table use
An example use of the Table option in Simple mode is to simulate the effect of adding several infusions of 50 dose units infused at a rate of 100 every 72 time units. Check the ADDL box in the Input Options tab and press Add. Then enter values for the dosing regimen as shown below.
In the Run Options tab, the N Iter should be set to zero so that the estimates are fixed. The Simple mode Table can be specified to output the times desired to see simulated concentrations.
For example:
This example is to output times from zero to 600 in increments of 0.5. Note that requesting the variable “C” indicates that predicted concentration values (C) should be recorded at the times requested, when doses are added to the amount in the central compartment (A1), and when concentrations are observed (CObs).