The Annotation block is used to add notes to a model.
Insert an Annotation block by selecting Insert > Annotation from the right-click menu.
With the Annotation block selected, type a note or description in the Note field.
Check the Border box to add a border to the annotation.
Annotation blocks do not wrap the text.
Press ENTER to add another line to the annotation.
If the Annotation block has a border, the block can be expanded to surround the text.
1. Select the block.
2 Place the cursor over one of the blue squares on the corners of the Annotation block.
3. Single-click and drag the blue square to expand the block around the text.
Use a vascular flow to represent blood flow in physiologically based PK models. This flow can connect PK compartments representing organs or other areas into circuits of blood flow. The flow rate between organs is represented by the variable Q.
1. Insert a Vascular flow by selecting Insert > PBPK > Vascular Flow from the right-click menu.
2. Select the first compartment of the flow.
3. Select the second compartment of the flow.
Note: A Vascular Flow should connect a central or a peripheral compartment. It should not be used to connect an elimination or an absorption compartment.
4. With the Vascular Flow selected, press the Draw button multiple times to toggle through the options for drawing the PK flow in the Graphical model interface.
Diagonal: Draws the diagonal flow.
Horizontal First: Draws the flow horizontally from the first compartment.
Vertical First: Draws the flow vertically from the first compartment.
5. In the CL field, enter a name for the input variable or use the default.
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