Main Mappings panel

Mappings panels identify how input variables are to be used. Map the data by dragging the dataset from the Data folder to the Setup tab or use the icon_select_source icon in the Setup tab.

Once a dataset is mapped, use the option buttons in the Mappings panels to assign the columns in the dataset to the appropriate context associations. Required context mappings are colored orange.

None: Columns mapped to this context are not included in any analysis or output.

Sort: Categorical variable(s) identifying individual data profiles.

X: For Dissolution, Indirect Response, Linear, PD, and PK/PD Linked Models. The independent variable in a dataset.

Y: For Dissolution, Indirect Response, Linear, PD, and PK/PD Linked Models. The dependent variable a dataset. Not needed if the Simulation checkbox is selected.

Time: Relative or nominal dosing times used in the study.

For Michaelis-Menten, PK, and ASCII Models.

Concentration: The measured amount of a drug in blood plasma.

For Michaelis-Menten, PK Models, and ASCII Models. Not needed if the Simulation checkbox is selected.

Function: For ASCII Models. Model function.

Carry: Variable(s) to copy to the output worksheets.

Note that time-dependent data variables (those that change over the course of a profile) are not carried over to time-independent output (e.g., Final Parameters), only to time-dependent output (e.g., Summary).

Weight: For Indirect Response, PK, PD, and PK/PD Linked Models. Used if weighting data is contained in the dataset. This column is only available if User Defined and Source are selected in the Weighting/Dosing Options tab.

Note:    When using a PK operational object, external worksheets for stripping dose, units and initial estimates can be accessed in different ways. The differences will occur if there is more than 1 row of information on these external worksheets that correspond to one or more individual profiles of data of the Main input worksheet. In such cases, the stripping dose for PK models will be determined as the first value found on that external worksheet whereas the units and initial parameters will be based on the last row found on those external worksheets (for any given profile). To avoid any confusion stemming from these differences, it is suggested that external worksheets maintain a one-to-one row-based correspondence to the Main input profiles whenever possible.


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