The Correlation tab and Correlation Estimates panel support the creation and validation of an InVitro-InVivo correlation model for the dissolution data mapped to the InVitro Data mapping panel, and the absorption data that is either generated from the deconvolution step in the InVivo settings tab or is mapped to the InVivo Fit mapping panel. The correlation is built using the formulations identified as Internal in the InVitro Formulation mapping panel. The IVIVC object fits the selected correlation model to absorption data using the dissolution profiles from the InVitro Data panel as inputs to the correlation function.
To validate the correlation, Phoenix can estimate AUCs and maximum concentrations based on the model predictions and compare the estimates to actual values from the in vivo data. To perform the estimations and comparison, Phoenix convolves predicted fractions absorbed and UIRs, then runs noncompartmental analysis on the predicted PK data and the observed in vivo data.
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