Linear block

The Linear block provides a simple linear model in the form: Output=A*Input+B.

The Linear block contains four input nodes and one output node. The input nodes are made available depending on the options that are selected in the Structural tab. If an input node cannot be used, it is marked with an X.

The input nodes on the Linear block can be connected to output nodes on PK compartments, observation blocks, PD blocks, and parameter blocks. Once an output node is connected, its name cannot be changed.

Insert a linear block by selecting Insert > PD > Linear from the right-click menu.

To specify Linear block options

Use the pointer to select a Linear block.
In the order menu, select the order of the linear model to determine how many parameters the Linear block uses.
In the Linear field, enter a name for the Linear block or use the default.
In each parameter field, accept the default names or type new names for each parameter.

Each parameter corresponds to an input node on the Linear block. Possible Linear parameters include:

C: drug concentration in plasma, or another input variable.
Alpha: coefficient for zero-order term.
Beta: coefficient for first-order term (if order >=1).
Gam: coefficient for second-order term (if order=2).