IVIVC Results

Results

Select the Results tab to view the output. IVIVC object output includes worksheets, plots, and text files. The lists of output in this section are grouped into tables based on the process by which they are generated.

Build correlation process output
Deconvolve data process and process output
Output for the fit dissolution step of Prediction
Output for InVitro stage of analysis
Output for Levy plot results of Percent absorbed vs percent dissolved
UIR Modeling output for InVivo stage
Predict PK process output
Validate correlation process output

Settings are not recorded on the History tab upon execution. However, they can be found in the individual Settings text output files for the different steps.

Note:Word Export is not recommended for IVIVC as the export would include all internal/hidden steps whose results are not readily discernible to the user.

Build correlation process output

Worksheet

Correlation.Abs vs Diss data: Fraction Absorbed vs Dissolved Data
Correlation.Correlation Overlay data: Fraction Absorbed vs Dissolved Overlay Data
Correlation.Correlation.*: Correlation Modeling Results
Correlation.Model Sim Vitro: Correlation Modeling Simulated Vitro Input
Correlation.Model Sim Vivo: Correlation Modeling Simulated Vivo Input
Correlation.Vitro Vivo Times: Used for in generating the Fraction Absorbed vs Dissolved plot. The tVitro added to Fa-Avg is based on the correlation function, all columns are removed except for formulation, tVivo, tVitro, and Mean

Plot

Correlation.Abs vs Diss Corr Overlay: Fraction Absorbed vs Dissolved with Correlation Overlay data. This plot is generated for built-in models, but not for user models.
Correlation.Correlation.*: Correlation Modeling Results

Text File

Correlation.Correlation.*: Correlation Modeling Results

Deconvolve data process and process output

Worksheet

Deconvolution Input: Input to the deconvolution step
Vivo.Deconvolution.Dosing: Deconvolution modeling output for InVivo stage of analysis
Vivo.Deconvolution.Exponential Terms: Deconvolution modeling output for InVivo stage of analysis
Vivo.Deconvolution.Fa-avg: Fa-Avg plot data
Vivo.Deconvolution.Fitted Values: Deconvolution modeling output for InVivo stage of analysis
Vivo.Deconvolution.Parameters: Deconvolution modeling output for InVivo stage of analysis
Vivo.Deconvolution.Values: Deconvolution modeling output for InVivo stage of analysis

Plot

Vivo.Deconvolution.Fa-Av: Fa-Avg overlaid. Average fraction absorbed by formulation. For the chart, Fabs grouped by subject with Fabs_avg overlaid and sorted by formulation. Not created if the Data already deconvolved and averaged option is selected, or if no sort variables are selected in the In-Vivo tab.
Vivo.Deconvolution.Fa-Av By Profile: Fa-Avg plot by profile. Fabs grouped by formulation, vs. time, and sorted by profile. Not created if the Data already deconvolved and averaged option is selected, or if no sort variables are selected in the In-Vivo tab.
Vivo.Deconvolution.Fitted Curves Plot: Deconvolution modeling output for InVivo stage of analysis
Vivo.Deconvolution.Input Rates Plot: Deconvolution modeling output for InVivo stage of analysis

Text File

Vivo.Deconvolution.Fa-avg: Descriptive Statistics settings for Fa-Avg
Vivo.Deconvolution.Settings: Deconvolution modeling output for InVivo stage of analysis

Output for the fit dissolution step of Prediction

Worksheet

Prediction.Diss.Condition Numbers
Prediction.Diss.Correlation Matrix
Prediction.Diss.Diagnostics
Prediction.Diss.Differential Equations
Prediction.Diss.Eigenvalues
Prediction.Diss.Final Parameters
Prediction.Diss.Final Parameters Pivoted
Prediction.Diss.Initial Estimates
Prediction.Diss.Minimization Process
Prediction.Diss.Partial Derivatives
Prediction.Diss.Predicted Data
Prediction.Diss.Secondary Parameters
Prediction.Diss.Secondary Parameters Pivoted
Prediction.Diss.Stacked Partial Derivatives
Prediction.Diss.Summary Table
Prediction.Diss.User Defined Settings
Prediction.Diss.VarianceCovariance Matrix

Plot

Prediction.Diss.Observed Y and Predicted Y vs X
Prediction.Diss.Partial Derivatives Plot
Prediction.Diss.Predicted Y vs Observed Y
Prediction.Diss.Predicted Y vs X
Prediction.Diss.Residual Y vs Predicted Y
Prediction.Diss.Residual Y vs X

Text File

Prediction.Diss.Core output
Prediction.Diss.Settings

Output for InVitro stage of analysis

Worksheet

Vitro.Dissolution.Condition Numbers
Vitro.Dissolution.Correlation Matrix
Vitro.Dissolution.Diagnostics
Vitro.Dissolution.Differential Equations
Vitro.Dissolution.Eigenvalues
Vitro.Dissolution.Final Parameters
Vitro.Dissolution.Final Parameters Pivoted
Vitro.Dissolution.Initial Estimates
Vitro.Dissolution.Minimization Process
Vitro.Dissolution.Partial Derivatives
Vitro.Dissolution.Predicted Data
Vitro.Dissolution.Secondary Parameters
Vitro.Dissolution.Secondary Parameters Pivoted
Vitro.Dissolution.Stacked Partial Derivatives
Vitro.Dissolution.Summary Table
Vitro.Dissolution.User Defined Settings
Vitro.Dissolution.VarianceCovariance Matrix

Plot

Vitro.Dissolution.Observed Y and Predicted Y vs X
Vitro.Dissolution.Partial Derivatives Plot
Vitro.Dissolution.Predicted Y vs Observed Y
Vitro.Dissolution.Predicted Y vs X
Vitro.Dissolution.Residual Y vs Predicted Y
Vitro.Dissolution.Residual Y vs X
Vivo.Deconvolution.Cumulative Input Plot

Text File

Vitro.Dissolution.Core output
Vitro.Dissolution.Settings

Output for Levy plot results of Percent absorbed vs percent dissolved

Worksheet

Levy Plots.%Abs vs %Diss.Levy Plot Values
Levy Plots.%Abs vs %Diss.Parameters
Levy Plots.Fabs vs Fdiss.Levy Plot Values
Levy Plots.Fabs vs Fdiss.Parameters

Plot

Levy Plots.%Abs vs %Diss
Levy Plots.Fabs vs Fdiss

UIR Modeling output for InVivo stage

Worksheet

Vivo.UIR.Condition Numbers
Vivo.UIR.Correlation Matrix
Vivo.UIR.Diagnostics
Vivo.UIR.Differential Equations
Vivo.UIR.Dosing Used
Vivo.UIR.Eigenvalues
Vivo.UIR.Final Parameters
Vivo.UIR.Final Parameters Pivoted
Vivo.UIR.Initial Estimates
Vivo.UIR.Minimization Process
Vivo.UIR.Partial Derivatives
Vivo.UIR.Predicted Data
Vivo.UIR.Secondary Parameters
Vivo.UIR.Secondary Parameters Pivoted
Vivo.UIR.Stacked Partial Derivatives
Vivo.UIR.Summary Table
Vivo.UIR.User Defined Settings
Vivo.UIR.VarianceCovariance Matrix

Plot

Vivo.UIR.Observed Y and Predicted Y vs X
Vivo.UIR.Partial Derivatives Plot
Vivo.UIR.Predicted Y vs Observed Y
Vivo.UIR.Predicted Y vs X
Vivo.UIR.Residual Y vs Predicted Y
Vivo.UIR.Residual Y vs X

Test File

Vivo.UIR.Core output
Vivo.UIR.Settings
Vivo.UIR.Warnings and Errors

Predict PK process output

Prediction.Baseline Stats: Observed summary stats used to calculate the errors
Prediction.Conv.Results: Simulation Convolution modeling output for Prediction Stage
Prediction.Corr Sim.*: Correlation modeling simulation output for Prediction step
Prediction.Model Sim *: Vitro/Vivo data used for Correlation Simulation
Prediction.Observed Baseline Nca.*: Observed NCA results
Prediction.Predicted Nca prediction.*: Predicted NCA results
Prediction.Predicted Stats: Predicted summary stats used to calculate the errors
Prediction.Prediction Errors: Prediction Errors

Validate correlation process output

Worksheet

Validation.Average Vivo.Statistics: Validation summary stats used to calculate the errors
Validation.Avg PE Stats: Validation percent error calculations
Validation.Baseline Stats: Observed summary stats used to calculate Validation errors
Validation.Conv.*: Simulation Convolution modeling output for Validation Stage
Validation.Corr Sim.*: Simulation Correlation modeling output for Validation Stage
Validation.Model Sim *: Correlation model simulation Vitro/Vivo input for Validation Stage
Validation.Observed Baseline Nca.*: Observed NCA analysis for Validation Stage
Validation.Predicted PK Nca.*: Predicted NCA analysis for Validation Stage
Validation.Predicted Stats: Predicted summary stats used to calculate Validation errors
Validation.Validation Errors: Validation Errors

Plot

Validation.Corr Sim.*: Simulation Correlation modeling output for Validation Stage
Validation.Observed Baseline Nca.Observed Y and Predicted Y vs X: Observed NCA analysis for Validation Stage
Validation.Predicted PK Nca.Observed Y and Predicted Y vs X: Predicted NCA analysis for Validation Stage
Validation.Val Conv Out: Convolution results for simulation part of Validation

Text File

Validation.Baseline Stats: Observed summary stats settings used to calculate Validation errors
Validation.Conv.Settings: Simulation Convolution modeling output for Validation Stage
Validation.Corr Sim.*: Simulation Correlation modeling output for Validation Stage
Validation.IVIVC.Validation: Settings for the filter prior to generation of Validation Errors
Validation.Observed Baseline Nca.*: Observed NCA analysis for Validation Stage
Validation.Predicted PK Nca.*: Predicted NCA analysis for Validation Stage
Validation.Settings: Validation settings