Effect compartment block

This block represents an effect site for a PK/PD model with a delay between the central and effect-site concentrations, that is, plots of plasma concentration versus effect level show a counter-clockwise hysteresis. See Sheiner, Stanski, Vozeh, Miller and Ham (1979). Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharm Ther 25:358–71 for more about modeling data with a hysteresis in the concentration-effect plot.

The Effect Compartment block contains two input nodes and one output node. The input nodes are made available depending on the options that are selected in the Structural tab. If an input node cannot be used, it is marked with an X.

The input nodes on the Effect Compartment block can be connected to output nodes on PK compartments, observation blocks, PD blocks, and parameter blocks.

Once an output node is connected, its name cannot be changed.

Insert an Effect Compartment block by selecting Insert > PD > Effect Cpt from the right-click menu.

To specify Effect compartment block options

Use the pointer to select an Effect Compartment block.
In the Ce field, enter a name for the Effect Compartment block or use the default.
In the Ke0 field, enter a name or use the default of Ke0.

Ke0 is the exit rate constant from the effect compartment.