Sparse sampling NCA example

This example demonstrates how to model with sparse sampling. The time-concentration data is pro­vided in SparseSamplingChaioYeh.xls. The dosing and therapeutic response data are stored in SparseSamplingChaioYeh_sources.xls. These files are located in the Phoenix exam­ples directory.

The completed project (NCA.phxproj) is available for reference in …\Examples\WinNonlin.

Set up the NCA object

  1. From within an open project, import the two files …\Examples\WinNonlin\Supporting files\SparseSamplingChaioYeh.xls and SparseSamplingChaioYeh_­sources.xls.
    In the File Import Wizard dialog, select the Has units row option for Sheet 1 and Dosing work­sheets.

  2. Select Workflow in the Object Browser and then select Insert > NCA and Toolbox > NCA.

  3. Rename the NCA object just added as SparseSamplingChaioYeh.

  4. Drag the SparseSamplingChaioYeh worksheet from the Data folder to the SparseSamplingC­haioYeh object’s Main Mappings panel. Map the context as follows:
    Subject set to None context
    Time to Time context
    Conc to Concentration context

Set up for sparse sampling

  1. Select Dosing in the Setup list.

  2. Expand the SparseSamplingChaioYeh_sources item in the Object Browser Data folder and drag the Dosing item to the Dosing panel.
    Type is already mapped to the None context.
    Time is already mapped to the Time context.
    Dose is already mapped to the Dose context.

  3. Select Therapeutic Response in the Setup list.

  4. In the expanded SparseSamplingChaioYeh_sources item in the Object Browser Data folder, drag the TherapeuticResponse item to the Therapeutic Response panel.
    Lower is already mapped to the Lower context.

  5. In the Options tab, check the Sparse check box.

Execute and view the NCA results

All necessary settings are complete.

  1. Click execute_this_step_locally_button_15.png to execute the object. The results are displayed on the Results tab.

  2. In the Results tab, click Final Parameters.

    3. SparseSampling_Final_Parameters.png 

    Part of the Final Parameters worksheet

  3. Click Summary Table.

    4. SparseSampling_Summary_Table.png 

  4. Click Observed Y and Predicted Y vs X.

SparseSampling_Graph.png 

This concludes the sparse sampling example.

 

Last modified date:6/26/19
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