Drug effect NCA example

This example demonstrates how to model a urine study. The time range, concentration, and data are provided in nca_pd.xls. The dosing data are stored in nca_pd_sources.xls. These files are located in the Phoenix examples directory.

The completed project (NCA.phxproj) is available for reference in …\Examples\WinNonlin.

Set up the NCA object

1. From within an open project, import the two files …\Examples\WinNonlin\Supporting files\nca_pd.xls and nca_pd_sources.xls.
   In the File Import Wizard dialog, select the Has units row option for Sheet 1.

2. Select Workflow in the Object Browser and then select Insert > NCA and Toolbox > NCA.

3. Rename the NCA object just added as nca_pd.

4. In the Options tab, set the Model Type to Drug Effect (220).

5. Drag the nca_pd worksheet from the Data folder to the nca_pd object’s Main Mappings panel to map it as the input source.
   Map Time to the X context.
   Map Cortisol_RR to the Y context.

6. Select Dosing in the Setup list.

7. Expand the nca_pd_sources item in the Object Browser Data folder and drag the Dosing item to the Dosing panel.
   Type is already mapped to the None context.
   Time is already mapped to the Time context.

8. Select Partial Areas in the Setup list.

9. In the expanded nca_pd_sources item in the Object Browser Data folder, drag the PartialAreas item to the Partial Areas panel.
   Map Curve to the Area # context.
   Map Lower to the Start Time context.
   Map Upper to the End Time context.

10. Select Parameter Names in the Setup list.

11. In the expanded nca_pd_sources item in the Object Browser Data folder, drag the Names item to the Parameter Names panel.
    Map Name to the Parameter Name context.
    Leave Preferred mapped to the Preferred context.
    Map Include to the Include in Workbook context.

12. Select Slopes in the Setup list and enter the following information:
    For the first row:
    60 for Start Time
    67 for End Time
    Time Range for Fit Method
    Linear for Lin/Log
    
    For the second row:
    125 for Start Time
    133 for End Time
    Time Range for Fit Method
    Linear for Lin/Log

13. Select Therapeutic Response in the Setup list, check the Use Internal Worksheet box and enter the following information:
    2.5 for Baseline
    5 for Threshold

Execute and view the NCA results

All necessary settings are complete.

14. Click to execute the object. The results are displayed on the Results tab.

15. In the Results tab, click Final Parameters.

 

Part of the Final Parameters worksheet

16. Click Summary Table.

 

 

This concludes the drug effect example.

 

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Last modified date:6/26/19

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