Summary_of_Key

The following is a summary of the key points:

• In order to edit the structure or content of any portion of a sequence, the user account must have permission to perform publishing activities and have reserved the containing section.

For example, to add a file to Section 2.2 Introduction, you must have reserved that section for edit.

You should release sections as you finish with them so they can be edited by others or published and submitted.

• States are applied to file references, sections, sequences, and regulatory activities in order to prevent editing and accurately reflect their status with a regulatory agency.

States are manually controlled by a publisher, but setting of a state at a higher level (such as a section or sequence) automatically propagates state changes to elements contained within that level.

• Your changes are local to you until you save your work.

At that point, the central PUBLISH database is updated and changes become visible to other users of PUBLISH and REVIEW.

File transfer continues even if you close PUBLISH as long as your workstation remains connected to your network.

• After changes have been saved, your reviewers can review and comment on a sequence using GlobalSubmit REVIEW.

• The XML elements of a sequence are created when the sequence is published. At this point, it is ready for final validation and submission to a regulatory agency.