To remove a file reference, select the file reference and select Remove from the Manage or context menu. A removal confirmation popup will appear. Removal can be done in bulk by selecting the section to be removed in the Navigation pane.
Go to the Inventory tab.
Select a file reference and use the Control + A function to select all documents in the section.
Hit Delete on the keyboard or Remove from the Manage menu.
This will remove all selected references.
Note: Removing content is different than deleting it from the eCTD operator, which is discussed in the “Managing Lifecycle” section.
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